Endocrine Abstracts

Intensive insulin regimes are widely accepted as the best way to control diabetes in children as well as adults, and most centres in the UK offer support for intensive regimes. The emphasis on intensification of diabetes management in children and young people has implications for schools because children need injections, or to use an insulin pump, during the school day, which may not have been required in bi-daily injection regimes.Diabetes teams need t...

Background: The notion of ‘normal’ is dominant in the lives of children with type 1 diabetes and their parents, because living with diabetes not only makes families different but it also makes their pursuit of ‘normal’ more visible.Aim: To develop a theoretical understanding of how children and their parents living with type 1 diabetes construct and perceive ‘normal’, and how they integrate ‘normal’ into their dail...

Background: Continuous subcutaneous insulin infusion (CSII) is proving superior in reducing HbA1c compared to multiple daily injections (MDI) in both the adult and paediatric populations. This study aims to compare the two methods, and evaluate the importance of education when starting insulin pump therapy in children.Design: Patients who attended a ‘pump school’ provided by the Royal Manchester Children’s Hospital between January 2010 and...

Clinical, epidemiological and in-vitro studies have found evidence for an association between Vitamin D and diabetes. Vitamin D receptors are found on pancreatic beta-cells, suggesting they have a role in glycaemic control. Vitamin D analogues inhibit inflammatory cytokines involved in destruction of Beta-cells. This study aimed to assess the relationship between Vitamin D and glycaemic control, as measured by HbA1C, in a Type 1 (T1) diabetic paediatric population. HbA1C value...

Maintaining glycaemic control within recommended levels is crucial to minimise vascular complications associated with type 1 diabetes (T1D). Vitamin D is recognised as a vascular growth-factor. Detection of its receptors on pancreatic β-cells suggests it may have a role in glycaemic control. This study aimed to assess determinants of HbA1C including the potential influence of vitamin D status in a T1 diabetic paediatric population.Methods: Patients ...